Endocrine Abstracts

Cardiovascular disease is the leading cause of death globally and obesity is a major risk factor either directly or through its complications such as diabetes, dyslipidaemia and hypertension. While the residual risk after treating these complications is diminishing, obesity can drive risk through, for example causing systemic and paracrine inflammation. Weight loss either through dietary and behaviour change, anti-obesity medications and bariatric surgery has been shown to be ...

The growing adoption of bariatric surgery (BS) as treatment for severe and complex obesity, is resulting in the emergence of both iatrogenic and nosohypokatastatic (disease substitution) diseases. Malabsorption (an integral part of gastric bypass surgery) may compound mineral, vitamin and trace element deficiencies that also result from poor nutrition that can be worsened by the restricted intake imposed by BS. Thiamine deficiency (especially in those who have frequent vomitin...

The association (and similarities) of polycystic ovary syndrome with the metabolic syndrome, in which excessive (visceral) accumulation and insulin resistance are patho-physiologically linked suggests an important role for weight loss and weight loss maintenance both for symptom improvement and improved fertility in the short term, and reduced cardiovascular and metabolic risk over the patient’s lifetime. A number of studies have confirmed that in PCOS, dietary-induced we...

Background and objectives: Obesity is associated with a relatively high prevalence of anaemia and iron deficiency compared to normal weight individuals; the cause is unknown. We aimed to determine the prevalence of iron deficiency and anaemia in a severely obese cohort of bariatric surgery candidates, and to explore underlying associations with markers of nutrition and inflammation.Methods: In a retrospective review of 703 consecutive patients presenting...

Background and objectives: Vitamin D deficiency and insufficiency is common in obese individuals. We aimed to determine the prevalence of vitamin D insufficiency within a cohort of severely obese individuals, exploring potential underlying associations.Methods: In a retrospective analysis of 703 patients sequentially presenting for bariatric surgery assessment, 663 had complete demographic, anthropometric, and haematological measures (vitamin D, folate, ...